解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI gr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112444640
更新日期:2013-01-01 00:00:00
abstract::Angiotensin II receptor blockers (ARB) are often co-administered with a calcium channel blocker (CCB) for treating hypertension. In this open-label randomised study, untreated diabetic hypertensive patients were randomised to receive either olmesartan 20 mg/day or candesartan 8 mg/day for 12 weeks. Patients with blood...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164112447310
更新日期:2012-10-01 00:00:00
abstract::Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164111431471
更新日期:2012-04-01 00:00:00
abstract::The global prevalence of diabetes mellitus (DM) continues to climb, and is accompanied by an increase in DM associated complications, most often manifesting as coronary heart disease. Platelet dysfunction has been implicated as a central contributor to the increased risk of coronary artery disease in patients with DM,...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164111420890
更新日期:2011-10-01 00:00:00
abstract::Metabolic syndrome (MetS) is a clustering of atherosclerotic coronary heart disease risk factors. This post-hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg or rosuvastatin 10 mg in a cohort of 618 high-risk hypercholesterolaemic patients with (n=368) and without (n=217) MetS who had pr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1479164111418136
更新日期:2011-10-01 00:00:00
abstract::Prehypertension is considered to be associated with increased cardiovascular disease (CVD), and some data suggest that insulin resistance is common in this group. The goal of this study was to quantify insulin action by determining the steady-state plasma glucose (SSPG) concentration during the insulin suppression tes...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164110396919
更新日期:2011-01-01 00:00:00
abstract::Patients with diabetes mellitus (DM) have accelerated atherosclerosis, which is the main underlying factor contributing to the high risk of atherothrombotic events in these patients. Atherothrombotic complications are the leading cause of morbidity and mortality in patients with DM. Among factors contributing to the p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.1177/1479164110383994
更新日期:2010-10-01 00:00:00
abstract::To assess the non-LDL-C-related dyslipidaemia risk of MI, 823 men aged 23 to 65 with a first MI were compared with 823 MI-free PROCAM controls matched for sex, age, smoking, DM, BP and LDL-C. Overall, the odds of MI in men with HDL-C < 1.15 mmol/L were 2.6 times those of men with HDL-C >or= 1.15 mmol/L, and the odds o...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164110372640
更新日期:2010-07-01 00:00:00
abstract::Antidiabetic thiazolidinediones (TZDs) improve endothelial function in patients with or without type 2 diabetes. The present randomised, placebo-controlled, double-blind study examined the time course of a single dose of rosiglitazone on flow-mediated endothelium-dependent vasodilation (FMD), metabolic parameters, and...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164110367812
更新日期:2010-07-01 00:00:00
abstract::Flow-mediated dilatation evaluation using hand skin heating may possibly be more accurate than post-ischaemic hyperaemia to detect conduit artery endothelial dysfunction in type 1 diabetes. We measured in 24 type 1 diabetic patients (n=16 without microangiopathy) and 24 healthy matched subjects radial artery diameter ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.1177/1479164109360470
更新日期:2010-04-01 00:00:00
abstract::The first objective of this study was to determine the baseline prevalence of metabolic syndrome and its individual components using the NCEP-R/ATPIII criteria, IDF criteria for Europe, and IDF criteria for Africa: waist circumference of at least 94 cm for men and women. The second objective was to investigate the inc...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109346362
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Statins are extensively used for lowering LDL-cholesterol and reducing cardiovascular events. Recent studies have shown that statins have beneficial anti-inflammatory effects. We aimed to determine whether and how adipokines are regulated during statin treatment in type 2 diabetic patients. METHOD:In this st...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,随机对照试验
doi:10.1177/1479164109339966
更新日期:2009-10-01 00:00:00
abstract::Urate, a naturally-occurring antioxidant, is a marker/factor for cardiovascular disease. Hyperuricaemia is associated with IR, MetS and endothelial dysfunction. We characterised the associations between neurohormones, uricaemia, and glucose homeostasis in type 2 diabetes mellitus (T2DM) males. Cross-sectional; 705 T2D...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109336689
更新日期:2009-07-01 00:00:00
abstract:PURPOSE:To examine the relationship between leisure-time physical activity (LTPA) and the metabolic syndrome in the U.S. adult population. METHODS:The sample (N=5,620) in this cross-sectional study included adults aged 20 years and older. Physical activity was measured in two ways: a six-level measure based upon those...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.1177/1479164109336040
更新日期:2009-04-01 00:00:00
abstract::We investigated the effect of atorvastatin monotherapy and combined treatment with atorvastatin and pioglitazone on intima-media thickness, vascular function and the cardiovascular risk profile. In all, 148 patients (76 male, 72 female; aged 61.4+/-6.5 years; body mass index [BMI] 29.2+/-4.1 kg/m2; mean +/- SD) with i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.043
更新日期:2008-11-01 00:00:00
abstract::The objective of this study was to evaluate the safety and tolerability of atorvastatin 10 mg compared with placebo in 2,838 patients with type 2 diabetes and no history of coronary heart disease who were enrolled in the Collaborative Atorvastatin Diabetes Study (CARDS) and followed for 3.9 years. The percentages of p...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2008.029
更新日期:2008-09-01 00:00:00
abstract::Adiponectin circulates in plasma as various isoforms. However, the biological activity of each isoform has not been firmly established. High molecular weight (HMW) adiponectin may be the active form of adiponectin, while a proteolytic cleavage product of adiponectin, known as globular adiponectin (gAd), has recently b...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.020
更新日期:2008-06-01 00:00:00
abstract::The aim of this study was to characterise microvascular blood flow in the skin and to compare it with biomarkers of endothelial dysfunction and tissue inflammation in patients with type 2 diabetes with (n=20) or without (n=20) microvascular complications and 20 control subjects. Microvascular function was measured by ...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2008.006
更新日期:2008-03-01 00:00:00
abstract::With the growing prevalence of childhood obesity and type 2 diabetes mellitus (T2DM) in youth, the challenge of cardiovascular disease risk management has entered the paediatric realm, affecting specialists, family physicians and allied healthcare professionals alike. Currently, there is little evidence to support opt...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.057
更新日期:2007-12-01 00:00:00
abstract::Vascular complications associated with type 2 diabetes confer significant morbidity and mortality. Atherosclerosis develops much earlier and progresses more rapidly than in subjects without diabetes. The clustering of cardiovascular risk factors associated with type 2 diabetes is mainly responsible for accelerated ath...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.067
更新日期:2007-12-01 00:00:00
abstract::This study assessed the effects of tesaglitazar (0.5 or 1 mg/day), a dual peroxisome proliferator-activated receptor alpha/gamma agonist, when added to maximally tolerated metformin (2-2.5 g/day) in patients with poorly controlled type 2 diabetes. The primary end point of this 24-week, randomised, placebo-controlled s...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3132/dvdr.2007.041
更新日期:2007-09-01 00:00:00
abstract::Roux-en-Y bypass surgery is increasingly used for treatment of gross obesity due to the general inability of lifestyle change and existing drug treatments to counter the obesity epidemic. This common form of bariatric surgery involves bypass of the small intestine with significant reduction of body of weight that is i...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2007.034
更新日期:2007-06-01 00:00:00
abstract::Insulin resistance typically reflects multiple defects of insulin receptor and post-receptor signalling that impair a diverse range of metabolic and vascular actions. Many potential intervention targets and compounds with therapeutic activity have been described. Proof of principle for a non-peptide insulin mimetic ha...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2007.002
更新日期:2007-03-01 00:00:00
abstract::Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) provide a strategy for the treatment of type 2 diabetes. DPP IV rapidly inactivates the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Inhibition of DPP IV prolongs and enhances the activity of endogeno...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2006.024
更新日期:2006-12-01 00:00:00
abstract::To assess the prevalence of metabolic syndrome (MS) and estimates of global risk by Framingham Risk Score in young subjects with acute myocardial infarction (MI), we assessed metabolic parameters and global risk assessment in 165 consecutive subjects who presented with myocardial infarction prior to 45 years of age. N...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章
doi:10.3132/dvdr.2006.012
更新日期:2006-09-01 00:00:00
abstract::The aim of this study was to evaluate changes in lipid profiles in patients with type 2 diabetes after treatment conversion from rosiglitazone to pioglitazone while maintaining stable statin and other lipid-altering therapies. A total of 305 patients were enrolled in this open-label study. Patients had been taking sta...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3132/dvdr.2006.005
更新日期:2006-05-01 00:00:00
abstract::In order to discuss and establish a joint position on the treatment of low serum levels of high-density lipoprotein cholesterol (HDL-C), a group of experts involved in the care of people with dyslipidaemia and at risk of cardiovascular disease met in Miami, Florida, U.S., on 5th and 6th March 2005. The experts came fr...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,实务指引
doi:10.3132/dvdr.2005.016
更新日期:2005-10-01 00:00:00
abstract::Cardiovascular disease is the most common complication of type 2 diabetes mellitus (type 2 DM), accounting for approximately 80% of deaths. While atherosclerotic vascular disease accounts for much of the cardiovascular morbidity and mortality among diabetic patients, congestive heart failure (CHF) is another key compl...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2005.010
更新日期:2005-05-01 00:00:00
abstract::There are few data concerning the relationship between diabetes mellitus, the metabolic syndrome and inflammation following elective percutaneous coronary intervention (PCI). The purpose of this study was to assess basal and peak levels of candidate cytokines in 40 patients undergoing elective PCI. Patients were categ...
journal_title:Diabetes & vascular disease research
pub_type: 临床试验,杂志文章
doi:10.3132/dvdr.2005.003
更新日期:2005-02-01 00:00:00
abstract::The complications of diabetes are myriad and represent a rising cause of morbidity and mortality, particularly in the Western world. The update of the Diabetes Control and Clinical Trials Group/Epidemiology of Diabetes Interventions and Complications Research Group (DCCT/EDIC) suggested that previous strict control of...
journal_title:Diabetes & vascular disease research
pub_type: 杂志文章,评审
doi:10.3132/dvdr.2004.001
更新日期:2004-05-01 00:00:00